This worksheet was designed for 2nd year biology (AP Biology) as a way for students to review the structure of DNA and the history of the experiments that lead to its establishment as the molecule of heredity.

Historical references include those related to Frederick Griffith’s experiments with transformation in bacteria and Hershey-Chase experiments with bacteriophages.

A DNA molecule is included for students to label the bases, nucleotides, and the 3′ and 5′ ends of the molecule.

Time Required: 15-20 minutes
Grade Level: 9-12